Cyclic Nucleotide Concentrations in 7,12-Dimethylbenz[a]anthracene-Induced Pancreatic Cancer in Rats2
| Autor: | E.S. Meek, H. F. Cheng, J. M. Graves, J. W. Osborne, R. H. Stevens, D. P. Loven |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Cancer Research
medicine.medical_specialty 7 12-Dimethylbenz[a]anthracene DMBA Cancer medicine.disease Cyclic nucleotide chemistry.chemical_compound Cyclic gmp Endocrinology medicine.anatomical_structure Oncology chemistry Pancreatic cancer Internal medicine medicine Pancreas 9 10 dimethyl 1 2 benzanthracene |
| Zdroj: | JNCI: Journal of the National Cancer Institute. 61:1281-1283 |
| ISSN: | 1460-2105 0027-8874 |
| DOI: | 10.1093/jnci/61.5.1281 |
| Popis: | Pancreas cancer was induced in noninbred male Holtzman rats by the implantation of beeswax containing 7.12-dimethylbenz[a]anthracene (DMBA) into the "head" of the pancreas. The tumors that developed 4--6 months later were examined for their cyclic AMP and cyclic GMP levels. The lesions could be considered in one of two categories according to their cyclic nucleotide contents: lesions with significantly smaller amounts and those with greater amounts, compared with levels measured in the pancreas tissues of the control rats. The existence of two biochemically distinct groups may indicate different growth patterns of the DMBA-induced pancreatic neoplasia. |
| Databáze: | OpenAIRE |
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