| Autor: |
Steven S. Matsumoto, Howard B. Cottam, Stewart Geary, Jack D. Anderson, Roger J. Bontems, Steven B. Larson, Donald F. Smee, Roland K. Robins |
| Rok vydání: |
1989 |
| Předmět: |
|
| Zdroj: |
Nucleosides and Nucleotides. 8:1201-1216 |
| ISSN: |
0732-8311 |
| Popis: |
Tubercidin (7-deazaadenosine, 1a) and several 6-chlorotuber-cidin derivatives were synthesized including 4-amino-6-chloro-7-β-D-ribofuranosylpyrrolo[2,3-d]pyrimidine-3′,5′-cycyclic phosphate 9. Isolation of a side product found in the glycosylation step of the reaction sequence proved to be the N-1 ribosyl-attached isomer as shown by X-ray diffraction analysis. All derivatives were tested for in vitro antiviral and antitumor activity. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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