Synthesis of nitrooxazoles
| Autor: | W. James Hammar, Mark A. Rustad |
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| Rok vydání: | 1981 |
| Předmět: | |
| Zdroj: | Journal of Heterocyclic Chemistry. 18:885-888 |
| ISSN: | 1943-5193 0022-152X |
| Popis: | A reaction sequence involving halogenation and replacement of the halo substituent by a nitro group using dinitrogen tetraoxide has led to a general, convenient route to 5-nitrooxazoles. Reaction schemes employing both bromine and iodine as the halo substituent have been investigated; however, the method using iodine preceded by a mercuration step affords a better overall yield in the range of 20–50%. Both 2- and 4-nitro-oxazoles can be prepared by this latter sequence, though in lower overall yields (4–12%). |
| Databáze: | OpenAIRE |
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