Reactive Centers of Curcumin and the Possible Role of Metal Complexes of Curcumin as Antioxidants

Autor:	P.V. Mohanan, S. Balachandran, Joseph. Daisy, Priya. R. S
Rok vydání:	2015
Předmět:	Physics Antioxidant DPPH medicine.medical_treatment Combinatorial chemistry Tautomer Ion formation Metal chemistry.chemical_compound chemistry visual_art Curcumin visual_art.visual_art_medium medicine Moiety Chelation
Zdroj:	Universal Journal of Physics and Application. 9:6-16
ISSN:	2331-6543 2331-6535
DOI:	10.13189/ujpa.2015.030102
Popis:	Curcumin is known as a blood purifier in Ayurveda which has been recently ascribed to its chelating ability with metal, hence reducing the deposition of metal in the body. Curcumin can exhibit keto-enol tautomerism and in the synthesized 1:1 metal complexes, the enolate ion chelate to the metal. The antioxidant activity of the synthesized metal complexes of curcumin was slightly less than the parent curcumin-I. Curcumin in the complexed state retains its antioxidant behavior, consequently establishing importance of phenolic group in deciding its antioxidant activity. The study reveals that the flexibility at the diketo moiety is not a requisite for the radical formation and sufficient scavenging of DPPH occur by phenoxide ion formation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ed1a58d2532d2bc8ce5f9805233be635 https://doi.org/10.13189/ujpa.2015.030102 Zobrazit plný text záznamu