Insulin antibodies in response to human insulin therapy in infants. 393

Autor:	Carlos E. Blanco, Nico J Jansen, Paul P. Menheere, Carine E De Beaufort, Michelle Deberg, F. Sodoyez-Goffaux, Paul Houssa
Rok vydání:	1997
Předmět:	medicine.medical_specialty biology business.industry Insulin medicine.medical_treatment Insulin Antibody Endocrinology Internal medicine Reference values Pediatrics Perinatology and Child Health medicine Human insulin biology.protein Antibody business
Zdroj:	Pediatric Research. 41:68-68
ISSN:	1530-0447 0031-3998
Popis:	It is known that in diabetic children insulin therapy induces insulin antibodies (IA), we wondered whether this response could be present in premature infants. Reference values for insulin and IA's were measured in 8 control infants, matched for GA and age. In this study insulin and IA's were measured before insulin therapy (T0), immediately after stop (T1) and 8 weeks later (T2) in 10 infants with a mean postconceptional age of 31 weeks, a mean BW of 1237 grams +/- 711) treated with continuous intravenous infusion of human insulin (NOVO) for at least 24 hours. Moreover, samples were also taken from 6 infants with a mean postconceptional age of 30 weeks, a mean BW of 908 grams +/- 374) treated with insulin 9 - 22 months before. Blood samples were collected from the mothers of the 3 groups of infants.Insulin was measured by RBA, IA's were measured by RBA and by ELISA. Levels for insulin antibodies were within the range of controls. This could mean that either insulin-treated premature infants are not able to produce antibodies, or that the stimulus for production was not sufficient. Table
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ed1a52fbbeafb119827e3cc40c70bf7b https://doi.org/10.1203/00006450-199704001-00413 Zobrazit plný text záznamu