A Study of Seven Different Salts of Penicillin
| Autor: | C.W. Price, Ruth P. Davis, Henry Welch, Velma L. Chandler |
|---|---|
| Rok vydání: | 1945 |
| Předmět: |
chemistry.chemical_classification
Calcium hydroxide Sodium bicarbonate Magnesium chemistry.chemical_element Salt (chemistry) Potassium bicarbonate Microbiology chemistry.chemical_compound Infectious Diseases chemistry Strontium hydroxide Sodium sulfate Anhydrous Immunology and Allergy Nuclear chemistry |
| Zdroj: | Journal of Infectious Diseases. 76:52-54 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/76.1.52 |
| Popis: | In a previous publication' it was demonstrated that the toxicity of 6 salts of penicillin was primarily due to the cations used in their preparation, and that the relative toxicity of the salts studied, in order of increasing toxicity, was Na, NH4, Sr, Ca, Mg and K. All of the above salts were prepared on a small scale under laboratory conditions. In extending this investigation, studies have been made of another group of 7 salts of penicillin produced commercially.* These salts, which included those listed above as well as The chloroform layer was separated, dried with anhydrous sodium sulfate, and held at -3 C. For the preparation of the individual salts aliquot portions were taken and extracted to a PH of 6.5 to 6.8 with aqueous solutions or suspensions of lithium carbonate, sodium bicarbonate, potassium bicarbonate, ammonium hydroxide, calcium hydroxide, strontium hydroxide and magnesium carbonate. The aqueous penicillin salt solutions measured about 300 cc for each 4,000,000 units. The solutions were adjusted to PH 6.1 to 6.2 with lac |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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