Influence of the Young’s Modulus of Polyurethane Implants on the Organism’s Immune Response
| Autor: | V. N. Terpugov, Alexey Kondyurin, Irina Kondyurina, V. S. Chudinov |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Low modulus
Materials science Biomechanical stress 0206 medical engineering Biomedical Engineering Medicine (miscellaneous) Soft tissue Young's modulus 02 engineering and technology 020601 biomedical engineering Medical Laboratory Technology symbols.namesake chemistry.chemical_compound Immune system chemistry symbols Implant Composite material Elasticity (economics) Polyurethane |
| Zdroj: | Biomedical Engineering. 52:431-434 |
| ISSN: | 1573-8256 0006-3398 |
| DOI: | 10.1007/s10527-019-09863-7 |
| Popis: | A series of polyurethanes with low modulus of elasticity for soft tissue implantation was synthesized. Polyurethane samples were implanted into mice for seven days, after which histological studies of capsule formation were carried out. The mechanical properties of polyurethane were found to affect the organism’s immune response at sites close to implants at which specific conditions concentrating biomechanical stress in tissues, particularly around the ends of polyurethane films, occur. Softer polyurethane with a modulus of elasticity close to the modulus of elasticity of tissues produced essentially no reaction to biomechanical stress, though reactions to the foreign surface of the implant remained. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink