| Autor: |
Sam J. Piliero, Louis J. Ignarro, Norbert Gruenfeld, Jan W. F. Wasley, Doebel Karl J, Mary Lee Graeme |
| Rok vydání: |
1969 |
| Předmět: |
|
| DOI: |
10.1016/s0065-7743(08)60659-4 |
| Popis: |
Publisher Summary This chapter elaborates studies analyzing non-steroidal anti-inflammatory agents. The importance of the circulating lymphocyte in association with the auto-immune component of adjuvant disease was shown by studies with heterologous antirat lymphocyte serum which prevents secondary responses to complete adjuvant. The RNA/DNA ratio of the lymphocyte may be a useful means of measuring immunological activity of an agent. The theory that enzymes released from lysosomes may denature the native constituents of cells of connective tissue and induce the formation of circulating antibodies as part of the normal immune response appears to be a strong possibility in the adjuvant disease of the rat. The increase in serum lysozyme levels observed in the polyarthritic rat may reflect the release of enzymes from leukocytic cells of the inflamed areas into the circulation. Phenylbutazone and indomethacin were found to be effective in preventing such increases. An impressive number of arylacetic and aryl-alkanoic acids with significant anti-inflammatory properties were reported. Myalex ® (ICI 54450) was clinically effective in rheumatoid arthritis. Activity was also reported for 5- p -chlorophenyl-2-furanacetic acid. In another study, anti-inflammatory activity was claimed for phenylacetic acids substituted in the 4-position by heterocyclic systems, pyrryl, phenyl, and benzoyl. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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