P143 Changes in the Clinical Phenotype and Behavior of Pediatric Luminal Crohn’s Disease at Diagnosis in the Last Decade

Autor: S Sassine, M Savoie-Robichaud, Y F Lin, L Djani, C A Christine, M Qaddouri, S Fadela Zekhnine, K Grzywacz, V Groleau, M Dirks, É Drouin, U Halac, V Marchand, C Girard, O Courbette, N Patey, D Dal Soglio, C Deslandres, P Jantchou
Rok vydání: 2022
Předmět:
Zdroj: Journal of Crohn's and Colitis. 16:i224-i225
ISSN: 1876-4479
1873-9946
Popis: Background Crohn’s disease (CD) triggers are incompletely understood and the incidence of the disease has been increasing. The aims of this study were to describe the trends in the clinical, endoscopic, histological, and laboratory characteristics of pediatric CD during the last decade and to describe the seasonal variation of disease presentation at diagnosis. Methods Patients under 18 years old and diagnosed between 2009 and 2019 were included. Patients clinical, endoscopic, histological, and laboratory data were collected from the medical records. Data were analyzed for the cohort as a whole and according to diagnostic periods (2009–2014 and 2015–2019) and seasons. Results 654 patients were included in the study. The total number of incident CD cases significantly increased yearly. Patients diagnosed between 2015 and 2019 were younger at diagnosis (OR: 2.30, p There were fewer CD diagnosis during winter. The highest vitamin D levels in patients occurred in summer and fall, but the majority of patients had, regardless of the season of diagnosis, severe vitamin D deficiency (the median vitamin D level was 60.0 nmol/L in summer and fall compared to 47.0 nmol/L in winter-spring, p=0.003). Vitamin D levels at diagnosis are inversely correlated with PCDAI (Pearson correlation coefficient = -0.19, p=0.03) and SES-CD (-0.20, p=0.04). Patients diagnosed in fall had lower PCDAI and SES-CD scores, less failure to thrive, less digestive symptoms and less extensive digestive involvement. Colonic disease was significantly more frequent during summer and fall (27.3% of patients diagnosed in summer and fall versus 18.2% of cases in winter and spring, p=0.01). Figure 1:PCDAI at diagnosis according to the season. Figure 2:Proportion of patients with L1-L2-L3 disease locations by the Paris classification according to the season of diagnosis. Conclusion The disease phenotype has changed over the years and there are important seasonal trends in the frequency and severety of the disease suggesting possible disease triggers. Our findings provide interesting avenues for future research, such as identifying the clinical significance of granulomas, vitamin D deficiency and microbiota on pediatric CD activity.
Databáze: OpenAIRE
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