Efficient Synthesis and Antibacterial Activities of Some Novel 1,2,3-Triazoles Prepared from Propargylic Alcohols and Benzyl Azides

Autor:	Maryam Mohadjerani, Mojtaba Mohseni, Mohammadreza Khadem Abolfazli, Rahman Hosseinzadeh, Zahra Lasemi
Rok vydání:	2014
Předmět:	Sodium ascorbate biology Pseudomonas aeruginosa Organic Chemistry Regioselectivity Bacillus subtilis biology.organism_classification medicine.disease_cause Minimum inhibitory concentration chemistry.chemical_compound chemistry Staphylococcus aureus medicine Organic chemistry Antibacterial activity Escherichia coli
Zdroj:	Journal of Heterocyclic Chemistry. 51:1298-1305
ISSN:	0022-152X
DOI:	10.1002/jhet.1680
Popis:	A simple and effective procedure for regioselective preparation of 1,2,3-triazoles from benzyl azides and propargylic alcohols is described using CuSO4.5H2O and sodium ascorbate. To screen the antibacterial activity of some newly synthesized triazole derivatives, minimum inhibitory concentration of 3d and 3k was evaluated against gram positive Staphylococcus aureus and Bacillus subtilis and gram negative Escherichia coli and Pseudomonas aeruginosa.
Databáze:	OpenAIRE
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