| Autor: |
Yucel Erbilgin, Müge Aydin Sayitoğlu, Ozden Hatirnaz Ng, Fulya Küçükcankurt |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Istanbul University Institute of Health Sciences Journal of Advanced Research in Health Sciences. 3 |
| ISSN: |
2651-4060 |
| Popis: |
Objective: Impaired activation of the PI3K/AKT signaling pathway has been associated with tumor development. The PTEN/AKT pathway plays a critical role in cell growth and survival and has been associated with chemotherapy resistance in leukemia. In this study, PTEN and AKT1 gene expression were determined in childhood T-ALL patients, and the effect was investigated on the prognosis of the disease. Materials and Methods: Bone marrow samples from 39 childhood cases were obtained at the time of diagnosis and screened with real-time quantitative PCR for PTEN and AKT1 genes. Results: In our study, no difference between T-ALL patients compared to controls was observed in PTEN gene expression whereas AKT1 gene expression was significantly increased (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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