Efficacy of immunomodulatory therapy with interferon-β or glatiramer acetate on multiple sclerosis-associated uveitis
| Autor: | C. Macia-Badia, José García-Arumí, A. Segura-García, S. Pastor Idoate, Daniel Velazquez-Villoria, L. Velez-Escola, G. Arcos-Algaba |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Retinal vasculitis business.industry Multiple sclerosis Inflammation General Medicine medicine.disease Gastroenterology Rash 03 medical and health sciences 0302 clinical medicine Interferon Internal medicine 030221 ophthalmology & optometry medicine Intermediate uveitis Glatiramer acetate medicine.symptom business 030217 neurology & neurosurgery Uveitis medicine.drug |
| Zdroj: | Archivos de la Sociedad Española de Oftalmología (English Edition). 92:273-279 |
| ISSN: | 2173-5794 |
| DOI: | 10.1016/j.oftale.2016.11.014 |
| Popis: | Aim To analyze the role of interferon-β or glatiramer acetate in reducing the inflammatory episodes of intra-ocular inflammation in multiple sclerosis-associated uveitis. Method A study was conducted on a non-randomized, retrospective case series of 13 patients with proven multiple sclerosis and uveitis (minimum follow-up, 12 months). All patients were given immunomodulatory treatment (interferon-β or glatiramer acetate) to control the course of the multiple sclerosis. Patients were compared to themselves before initiating the treatment, in order to assess the difference in uveitis episodes. The main outcome measurements were the number of uveitis episodes with/without immunomodulatory treatment. Results Uveitis was bilateral in 10 (77%) out of 13 patients. Intermediate uveitis was observed in 11 patients, retinal vasculitis in 3 patients, and one patient was classified as a posterior uveitis. The patients had a mean of 4.15 ± 3.1 episodes of uveitis (range 1–10) during the follow-up period (148.6 ± 84.3 months). When compared to their pre-treatment status, patients on treatment with interferon-β or glatiramer acetate showed a significant decrease of 0.36 episodes of ocular inflammation per year ( p = 0.02). Mild side effects related to immunomodulatory treatment were observed in 6 (46%) patients, 3 (23%) patients with a flu-like syndrome, and 3 (23%) patients with a skin rash. Conclusions Interferon β or glatiramer acetate could be effective in reducing the uveitis episodes in patients with multiple sclerosis-associated uveitis, and was well tolerated in most patients. |
| Databáze: | OpenAIRE |
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