Rh-Catalyzed General Method for Directed C–H Functionalization via Decarbonylation of in-Situ-Generated Acid Fluorides from Carboxylic Acids
| Autor: | Xiaofeng Zhang, Yuxi Ren, Xiaojie Liu, Weiping Su, Hongyi Li, Bangyue He |
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| Rok vydání: | 2021 |
| Předmět: |
In situ
chemistry.chemical_classification General method 010405 organic chemistry Chemistry Aryl Organic Chemistry Decarbonylation 010402 general chemistry 01 natural sciences Biochemistry 0104 chemical sciences Catalysis chemistry.chemical_compound Amide Surface modification Organic chemistry Physical and Theoretical Chemistry Alkyl |
| Zdroj: | Organic Letters. 23:4191-4196 |
| ISSN: | 1523-7052 1523-7060 |
| DOI: | 10.1021/acs.orglett.1c01103 |
| Popis: | A Rh-catalyzed decarbonylative C-H coupling of in-situ-generated acid fluorides with amide substrates bearing ortho-Csp2-H bonds has been developed. This method enables alkyl, aryl, and alkenyl carboxylic acids to undergo decarbonylative coupling with C-H bonds of (hetero)aromatic or alkenyl amides in generally good yields via the in situ conversion of carboxylic acids into acid fluorides and also allows for the functionalization of a series of structurally complex carboxyl-containing natural products and pharmaceuticals as well as pharmaceutical amide derivatives. |
| Databáze: | OpenAIRE |
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