| Autor: |
Anjaneyulu, Sadanani, Mohan Reddy. N, Kalyan Kumar Ch, Lakshmi Addala |
| Rok vydání: |
2012 |
| Předmět: |
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| Zdroj: |
Journal of Cancer Science & Therapy. |
| ISSN: |
1948-5956 |
| DOI: |
10.4172/1948-5956.1000139 |
| Popis: |
Background: The p53 protein has pleiotropic functions in the modulation of genomic stability of cells. Disruption of p53 activity is commonly found in human cancers. The p53 codon 72 polymorphism is likely to play an important role in the susceptibility to OSCC. We aimed to investigate the association of p53 codon 72 polymorphism with oral squamous cell carcinoma in south Indian population. Methods: We genotyped 150 OSCC patients and 150 controls, using PCR-RFLP method. Results: Our results showed a significant difference in the distributions of p53 codon 72 genotypes among cases and controls. Genotype frequencies of p53 Arg/Arg, Arg/Pro and Pro/Pro were 50.8, 33.9 and 14.4% in the oral squamous cell carcinoma patients and 48.7, 45.1 and 6.2% in the controls, respectively. Arginine/arginine genotype was elevated in controls compared to patients (P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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