The Dopamine D2 Receptor Locus as a Modifying Gene in Neuropsychiatric Disorders

Autor: Bejan Shahbahrami, Baumgarten R, David E Tast, D E Comings, Kocsis P, Comings Bg, D. Muhleman, Bruce W. Kovacs, George Dietz, E. Knell
Rok vydání: 1991
Předmět:
Zdroj: JAMA: The Journal of the American Medical Association. 266:1793
ISSN: 0098-7484
1793-1800
DOI: 10.1001/jama.1991.03470130073032
Popis: Objective. —The A1 allele of the Taq I polymorphism of the dopamine D 2 receptor ( DRD2 ) gene has been earlier reported to occur in 69% of alcoholics, compared with 20% of controls. Other research has reported no significant difference in the prevalence of the A1 allele in alcoholics vs controls and no evidence that the DRD2 gene was linked to alcoholism. We hypothesized that these seemingly conflicting results might be because increases in the prevalence of the A1 allele may not be specific to alcoholism. Thus, we examined other disorders frequently associated with alcoholism or those believed to involve defects in dopaminergic neurotransmission. Design. —Case comparison study. To minimize the effect of racial differences in gene frequencies, the study was restricted to non-Hispanic whites. Setting. —Ambulatory and hospitalized patients. Results. —Among all known controls (n = 314), 77 (24.5%) carried the A1 allele. Of the 69 controls known not to be alcoholics, 10 (14.5%) carried the A1 allele. The prevalence of the A1 allele was significantly increased in patients with Tourette's syndrome (44.9%, n = 147), attention deficit hyperactivity disorder (46.2%, n = 104), autism (54.5%, n = 33), alcoholism (42.3%, n = 104), and posttraumatic stress disorder (45.7%, n = 35). After correction for multiple comparisons (requiring P Conclusion. —These results suggest the A1 allele of the DRD2 gene is associated with a number of behavior disorders in which it may act as a modifying gene rather than as the primary etiological agent. ( JAMA . 1991;266:1793-1800)
Databáze: OpenAIRE
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