| Popis: |
The burden of the interpretation of the results of a long-term carcino-genicity study in rodents falls squarely on the shoulders of the pathologist: his findings have ultimate legal, economic and political connotations. There are three critical decision points — diagnosis, interpretation and evaluation. The diagnosis, as in man, depends on a full clinical history being correllated with the pathological findings. The most difficult task is to distinguish inflammation from hyperplasia, hyperplasia from neoplasia and the benign from the malignant form of the latter. Interpretation is deciding, with all the information available, chether the substance is carcinogenic in the rodent species employed and evaluation is deciding whether the substance should, therefore, be considered to be carcinogenic for man. |
