Immunoblastic lymphoma of small intestine complicating late-onset immunodeficiency
| Autor: | Juan C. Gonzalez-Vitale, Armond S. Goldman, Randall M. Goldblum, Luis G. Gomez, Marcel Patterson |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Cancer Research
Pathology medicine.medical_specialty biology business.industry Intestinal Neoplasm Context (language use) Late onset Hyperplasia medicine.disease Small intestine Hypogammaglobulinemia medicine.anatomical_structure Oncology hemic and lymphatic diseases Immunology medicine biology.protein Antibody business Immunodeficiency |
| Zdroj: | Cancer. 49:445-449 |
| ISSN: | 1097-0142 0008-543X |
| DOI: | 10.1002/1097-0142(19820201)49:3<445::aid-cncr2820490309>3.0.co;2-1 |
| Popis: | A malignant lymphoma of the small bowel developed in a 75-year-old woman who had severe late-onset hypogammaglobulinemia with intestinal malabsorption and nodular lymphoid hyperplasia. The tumor arose in the midst of the abnormal lymphoid follicles and appeared to be of B-immunoblastic type. Immunoperoxidase staining, however, failed to reveal immunoglobulins in the tumor cells. In vitro immunologic studies showed that immunoglobulin production by the patient's peripheral lymphocytes had decreased and that this decrease was mediated by hydrocortisone-sensitive suppressor cells. These findings suggest that nodular lymphoid hyperplasia of the intestine in the context of severe immunodeficiency is a premalignant condition. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text