ChemInform Abstract: Synthesis and Biological Activity of a Series of 4-Aryl Substituted Benz(b)azepines: Antagonists at the Strychnine-Insensitive Glycine Site

Autor:	Timothy Davenport, Paul F. Jackson, Gregory G. Harris, Laura Garcia, Jeffrey A. McKinney, James R. Damewood, Linda M. Pullan, Marc J. Chapdelaine, Margaret G. Melville, Jeffrey M. Goldstein
Rok vydání:	2010
Předmět:	chemistry.chemical_compound chemistry Stereochemistry In vivo Aryl Glycine Biological activity General Medicine Strychnine Azepine Glycine receptor Derivative (chemistry)
Zdroj:	ChemInform. 27
ISSN:	0931-7597
DOI:	10.1002/chin.199615188
Popis:	A series of 4-arylbenz[b]azepine analogs were prepared and shown to act as antagonists at the strychnine-insensitive glycine receptor. The heteroaryl substituted benz[b]azepine derivative 11 also showed excellent in vivo activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::eca26a5b5c511165119a61f05f46422a https://doi.org/10.1002/chin.199615188 Zobrazit plný text záznamu Plný text