Anterior cingulate cortex and cerebellar hemisphere neurometabolite changes in depression treatment: A1H magnetic resonance spectroscopy study

Autor:	Zhuo-Zhi Dai, Li-Ping Chen, Chong-Tao Xu, Renhua Wu, Hai-Yang Dai
Rok vydání:	2014
Předmět:	medicine.medical_specialty behavioral disciplines and activities chemistry.chemical_compound Internal medicine Cerebellar hemisphere mental disorders medicine Choline Anterior cingulate cortex Depression (differential diagnoses) General Neuroscience Glutamate receptor General Medicine medicine.disease Dorsolateral prefrontal cortex Psychiatry and Mental health medicine.anatomical_structure Endocrinology nervous system Neurology chemistry Anesthesia Major depressive disorder Antidepressant Neurology (clinical) Psychology
Zdroj:	Psychiatry and Clinical Neurosciences. 68:357-364
ISSN:	1323-1316
DOI:	10.1111/pcn.12138
Popis:	Aim We utilized single-voxel 1H magnetic resonance spectroscopy to determine biochemical abnormalities related to major depressive disorder (MDD) in the bilateral dorsolateral prefrontal cortex, anterior cingulate cortex (ACC), and cerebellar hemisphere before and after antidepressant treatment. Methods Fifteen adult MDD patients and 15 age- and sex-matched healthy controls were involved. Magnetic resonance spectroscopy of the brain was conducted in all subjects at the beginning of the study and the depressed subjects were reassessed after 8 weeks of antidepressant treatment. Results At baseline, N-acetyl aspartate (NAA), total glutamine plus glutamate (Glx) and myo-inositol (MI) levels in the bilateral ACC were significantly lower in MDD patients than in controls (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::eca21b93c7b511cf8346d5848613a95f https://doi.org/10.1111/pcn.12138 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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