Synthesis of Porphyrin and Bacteriochlorin Glycoconjugates through CuAAC Reaction Tuning
| Autor: | Nicole L. Snyder, Nikole L. Fendler, Melissa E. Lech, David G. Dennis, Matthew R. Parris, David N. Blauch, George T. Mukosera, Matthew C. Bennion, Kira Neuhaus, Charlie F. Dixon, Jessica E. Cuadra, Joshua V. Ruppel, Morgan A. Burch, Laura Hartmann |
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| Rok vydání: | 2019 |
| Předmět: |
chemistry.chemical_classification
Glycosylation 010405 organic chemistry Glycoconjugate medicine.medical_treatment Organic Chemistry Photodynamic therapy 010402 general chemistry 01 natural sciences Porphyrin Combinatorial chemistry Cycloaddition 0104 chemical sciences Catalysis chemistry.chemical_compound chemistry Yield (chemistry) Click chemistry medicine Physical and Theoretical Chemistry |
| Zdroj: | European Journal of Organic Chemistry. 2019:6496-6503 |
| ISSN: | 1434-193X |
| Popis: | Rapid and reproducible access to a series of unique porphyrin and bacteriochlorin glycoconjugates, including meso-glycosylated porphyrins and bacteriochlorins, and beta-glycosylated porphyrins, via copper catalyzed azide-alkyne 1,3-dipolar cycloaddition (CuAAC) is reported for the first time. The work presented highlights the system-dependent reaction conditions required for glycosylation to porphyrins and bacteriochlorins based on the unique electronic properties of each ring system. Attenuated reaction conditions were used to synthesize fifteen new glycosylated porphyrin and bacteriochlorin analogs in 74 - 99% yield, and were extended to solid support to produce the first oligo(amidoamine)-based porphyrin glycoconjugate. These compounds hold significant potential as next generation water soluble catalysts and photodynamic therapy/photodynamic inactivation (PDT/PDI) agents. |
| Databáze: | OpenAIRE |
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