| Popis: |
Fracture of the proximal end of the femur is one of the most common fractures in elderly patients. Worldwide, this type of fracture occurs in 2.5 m of people annually including approximately 30, 000 Poles. It usually occurs as a complication of osteoporosis. In the bones, changes in the level of cytokines following osteoporosis are observed. These changes refer mainly to pro-inflammatory cytokines: tumor necrosis factor α (TNF-α), interleukin 1 (IL-1) and interleukin 6 (IL-6). The aim of this preliminary study was to assess if there are any changes in the blood level of these cytokines in ostmenopausal patients with low-energy fracture of the proximal end of the femur. Additionally, the changes in cytokines concentration were also analyzed in conjunction with the body mass index, sex hormones (FSH and estradiol) as well as parameters connected with bone turnover (calcium, phosphorus). The study showed a significantly higher concentration of interleukin 1, interleukin 6 and TNF-α in patients with a low-energy fracture of the proximal end of the femur and confirmed the relationship between blood estradiol level and body mass index versus the tested fracture. |
