Comparing Oxidative Stress Markers and S100B, Aβ-40 Proteins as Independent Neurological Markers in Distinguishing the Relation of Alzheimer's Disease and Diabetes Mellitus
| Autor: | Gökhan Erkol, I. Murat Bolayirli, Sinem Firtina, Dildar Konukoglu |
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| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Isoprostane Adiponectin business.industry Insulin medicine.medical_treatment 030204 cardiovascular system & hematology medicine.disease Malondialdehyde medicine.disease_cause 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Insulin resistance Endocrinology chemistry Internal medicine Diabetes mellitus medicine Biomarker (medicine) business 030217 neurology & neurosurgery Oxidative stress |
| Zdroj: | Journal of Neurology and Neuroscience. |
| ISSN: | 2171-6625 |
| DOI: | 10.21767/2171-6625.1000146 |
| Popis: | Objective: This study compares biomarkers of oxidative stress and neurological in patients of Alzheimer's disease (AD) and Diabetes Mellitus (DM) to evaluate mechanisms of oxidative stress and inflammation in the pathogenesis of AD. Methods: Serum concentrations of 3-nitrotyrosine, Isoprostane, Protein Carbonyl, Malondialdehyde, Nitric Oxide, Asymmetrical Dimethyl-L-Arginine, Glutathione, and Homocysteine (as oxidative stress markers); adiponectin, fetuin A, insulin, soluble receptor of advanced glycation end products (sRAGE), IGF-I and Amylin (Insulin Resistance (IR) markers), serum amyloidβ (Aβ) and S100B protein (as neurological markers) were measured in controls, Type 2DM with or without AD, patients with AD with or without DM. Results: Even though levels of Aβ-40 was significantly higher in DM -OAD+ AD patients than DM-OAD patients (p |
| Databáze: | OpenAIRE |
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