Micropetrosis – Occlusion of Osteocyte Lacunae
| Autor: | Sofie Dragoun Kolibová, Björn Busse, Katharina Jähn-Rickert |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Osteologie. 31:280-288 |
| ISSN: | 2567-5818 1019-1291 |
| Popis: | This article summarizes the current knowledge on micropetrosis – osteocyte lacunar occlusion, while focusing on the latest data on osteocyte viability and diabetic bone disease. The lacunae are fluid-filled ellipsoid spaces where osteocytes reside within the mineralized matrix. During osteocyte lifetime, the lacunar space is kept in a non-mineralized state. However, a dying osteocyte appears to enable the initiation of lacunar mineralization – creating a fossil within the living tissue. Elevated frequencies of micropetrosis are observed with advanced age, but also type 1 diabetes mellitus. The latter is a common health threat to our society with rising numbers of patients suffering from the disease associated symptoms including a secondary type of osteoporosis with an elevated risk of fragility fractures. While the underlying mechanism of diabetic bone disease is not entirely understood, more evidence is pointing towards a combinatory effect of loss of bone mass and an impaired overall bone quality. The high number of micropetrotic osteocyte lacunae leads to a more brittle bone tissue prone to microcracking. Further investigations are required to determine the implications of elevated micropetrosis as a reliable target of bone fragility. |
| Databáze: | OpenAIRE |
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