Pure Red Cell Aplasia as Presentation of Systemic Lupus Erythematosus: Antibodies to Erythropoietin: CASE REPORT
| Autor: | A Fertakis, A. G. Tzioufas, G. D. Linardaki, Kyriaki A. Boki |
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| Rok vydání: | 1999 |
| Předmět: |
Systemic disease
Lupus erythematosus biology business.industry Immunology Antibody titer Pure red cell aplasia General Medicine Bone Marrow Aplasia medicine.disease Titer Rheumatology immune system diseases Erythropoietin hemic and lymphatic diseases medicine biology.protein Immunology and Allergy Antibody skin and connective tissue diseases business medicine.drug |
| Zdroj: | Scandinavian Journal of Rheumatology. 28:189-191 |
| ISSN: | 1502-7732 0300-9742 |
| DOI: | 10.1080/03009749950154293 |
| Popis: | In this case report we describe two patients with pure red cell aplasia (PRCA) as an initial manifestation of systemic lupus erythematosus (SLE). Antibodies to erythropoietin were determined, by an ELISA method developed in our laboratory, in frozen serum obtained from one of the patients. A high titer of antibodies to erythropoietin was detected in serum obtained before treatment with high dose intravenous immunoglobulin (IVIG). The antibody titer declined after successful treatment. This observation suggests that antibodies to erythropoietin may contribute to the pathogenesis of SLE associated PRCA. |
| Databáze: | OpenAIRE |
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