Time for a gut check: Pancreatic sufficiency resulting from CFTR modulator use
| Autor: | Elizabeth Champion, Jennifer L. Goralski, Vani V. Gopalareddy, Rosemary Megalaa |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Pulmonary and Respiratory Medicine
congenital hereditary and neonatal diseases and abnormalities medicine.medical_specialty biology business.industry Pancreatic exocrine insufficiency medicine.disease Cystic fibrosis Gastroenterology Cystic fibrosis transmembrane conductance regulator Ivacaftor 03 medical and health sciences 0302 clinical medicine 030228 respiratory system 030225 pediatrics Internal medicine Pediatrics Perinatology and Child Health medicine biology.protein business Cftr modulator medicine.drug |
| Zdroj: | Pediatric Pulmonology. |
| ISSN: | 1099-0496 8755-6863 |
| DOI: | 10.1002/ppul.24353 |
| Popis: | Pancreatic exocrine insufficiency in cystic fibrosis is genetically determined and generally felt to be irreversible. However, recent studies in young children started on cystic fibrosis transmembrane conductance regulator (CFTR) modulators have suggested improvement of pancreatic functioning over time. Here, we present the case of a 10-year-old child with pancreatic exocrine insufficiency since birth who regained pancreatic functioning after 4 years on the CFTR corrector drug, ivacaftor. |
| Databáze: | OpenAIRE |
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