Does intravenous ondansetron affect gastric emptying of a solid meal, gastric electrical activity or blood hormone levels in healthy volunteers?

Autor:	S. T. Lourens, Ulrich Scheurer, L Varga, Peter Netzer, H. Ledermann, C. Gaia, E. P. Ritter, Markus W. Büchler, S. Wildi, D. Lüscher, J.A. Kinser, U. Noelpp, P. Reber
Rok vydání:	2002
Předmět:	medicine.medical_specialty Hepatology Gastric emptying business.industry Stomach digestive oral and skin physiology Gastroenterology Motilin Ondansetron Gastric inhibitory polypeptide Endocrinology medicine.anatomical_structure Internal medicine medicine Pancreatic polypeptide Pharmacology (medical) business Gastrin Cholecystokinin medicine.drug
Zdroj:	Alimentary Pharmacology & Therapeutics. 16:119-127
ISSN:	0269-2813
DOI:	10.1046/j.1365-2036.2002.01152.x
Popis:	Background: In previous studies, tropisetron has been shown to accelerate gastric emptying of a solid meal. However, it is uncertain whether other specific 5-hydroxytryptamine-3 receptor antagonists, such as ondansetron, also have a gastroprokinetic effect in humans. Aim: To evaluate the effect of ondansetron on gastric half-emptying time (T1/2) of a solid meal, gastric myoelectrical activity and hormone levels in 14 healthy volunteers. Methods: In a placebo-controlled, randomized, crossover study, we investigated the effects of ondansetron (8 mg intravenously) on the gastric emptying of solids (by scintigraphy), gastric myoelectrical activity (by electrogastrography) and the post-prandial release of cholecystokinin, gastrin, human pancreatic polypeptide, gastric inhibitory polypeptide, vasoactive intestinal polypeptide, motilin, substance P and galanin. Results: The average T1/2 values were 86 min and 85.5 min without lag time (P=0.082) and 92 min and 93 min with lag time (P=0.158) for the placebo and ondansetron treatments, respectively. The average T1/2 of female volunteers was significantly longer than that of male volunteers. The dominant gastric electrical frequency and hormone plasma concentrations were not altered by ondansetron. Conclusions: Ondansetron did not affect the gastric emptying of solids, the dominant gastric electrical frequency or the plasma concentrations of the analysed gastrointestinal peptides.
Databáze:	OpenAIRE
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