Colored Dimeric Alkaloids from the Barks of Erythrina variegata and Their Neuroprotective Effects
Autor: | Qin-Gang Tan, Yang Yu, Mei-Fen Bao, Yu-Ting Tang, Johann Schinnerl, Jing Wu, Xiang-Hai Cai |
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Rok vydání: | 2021 |
Předmět: | |
Zdroj: | The Journal of Organic Chemistry. 86:13381-13387 |
ISSN: | 1520-6904 0022-3263 |
Popis: | Five dimeric Erythrina alkaloids, named erythrivarines J-N, were isolated from the barks of Erythrina variegata L. (Fabaceae). The erythrivarines J-L featured a 6/6/5/6/6/5/6/6/6 ring system and super conjugated double bond systems, causing intense color from blue to wine red, while erythrivarines M-N looked orange. The structures of the isolated compounds were elucidated by 1D and 2D NMR experiments combined with MS and confirmed by the X-ray crystal diffraction technique. The performed bioassay using HEI-OC-1 cells revealed neuroprotective properties of erythrivarine N against the hearing loss causing antibiotics, neomycin. |
Databáze: | OpenAIRE |
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