Colored Dimeric Alkaloids from the Barks of Erythrina variegata and Their Neuroprotective Effects

Autor:	Qin-Gang Tan, Yang Yu, Mei-Fen Bao, Yu-Ting Tang, Johann Schinnerl, Jing Wu, Xiang-Hai Cai
Rok vydání:	2021
Předmět:	Wine biology Stereochemistry Chemistry Organic Chemistry Neomycin Orange (colour) Fabaceae biology.organism_classification Neuroprotection medicine Two-dimensional nuclear magnetic resonance spectroscopy Erythrina medicine.drug
Zdroj:	The Journal of Organic Chemistry. 86:13381-13387
ISSN:	1520-6904 0022-3263
Popis:	Five dimeric Erythrina alkaloids, named erythrivarines J-N, were isolated from the barks of Erythrina variegata L. (Fabaceae). The erythrivarines J-L featured a 6/6/5/6/6/5/6/6/6 ring system and super conjugated double bond systems, causing intense color from blue to wine red, while erythrivarines M-N looked orange. The structures of the isolated compounds were elucidated by 1D and 2D NMR experiments combined with MS and confirmed by the X-ray crystal diffraction technique. The performed bioassay using HEI-OC-1 cells revealed neuroprotective properties of erythrivarine N against the hearing loss causing antibiotics, neomycin.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ec4a8079c14e28ce41076883ab07b825 https://doi.org/10.1021/acs.joc.1c01489 Zobrazit plný text záznamu