Study of the Nerve Apparatus and Mast Cells in the Hearts of Old Rats
| Autor: | E. I. Chumasov, E. S. Petrova, E. A. Kolos, D. E. Korzhevskii |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
education.field_of_study Tyrosine hydroxylase biology business.industry Population Connective tissue Mast cell chemistry.chemical_compound medicine.anatomical_structure Endocrinology chemistry Internal medicine medicine Synaptophysin biology.protein Geriatrics and Gerontology Axon education business Gerontology Histamine Tissue homeostasis |
| Zdroj: | Advances in Gerontology. 11:29-36 |
| ISSN: | 2079-0589 2079-0570 |
| DOI: | 10.1134/s2079057021010355 |
| Popis: | A comparative study of the nerve structures and the density of mast cells in the heart of rats aged 3–4 and 23 months was carried out with histological and histochemical methods and the immunohistochemical markers PGP 9.5, tyrosine hydroxylase (TH), and synaptophysin. It was found that tissues innervation decreases with aging in all studied heart areas, particularly, sympathetic innervation. A decrease in sympathetic plexus density and the presence of dystrophic and degenerative changes in TH-immunopositive axon terminals were registered. It was also demonstrated that the mast cell population in old animals increases in the connective tissue of the pericardial, in the epicardium, and the myocardium of atria and ventricles region upon a decrease in sympathetic innervation. It is suggested that the increase in the number of mast cells in the heart during aging occurs in response to a deficiency in catecholamines and is related to the mast-cell secretion of biologically active substances (heparin, histamine, and serotonin), which help maintain local tissue homeostasis and adaptive and compensatory reactions of the animal heart. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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