ChemInform Abstract: Preparation of Biotinylated Allosamidins with Strong Chitinase Inhibitory Activities

Autor:	Shohei Sakuda, Masaru Sakurada
Rok vydání:	2010
Předmět:	Strong inhibitor biology Chemistry Stereochemistry Trichoderma Biotinylation Chitinase biology.protein General Medicine Biotin hydrazide biology.organism_classification Inhibitory postsynaptic potential
Zdroj:	ChemInform. 30
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.199910221
Popis:	NaIO 4 oxidation of allosamidin ( 1 ), a strong inhibitor of family 18 chitinases, followed, followed by a coupling with Biotin Hydrazide R afforded its mono- and dibiotinylated derivatives, 4 and 6 . Reduction of 4 by NaBH 4 afforded its reduced form 5 . Each of these three biotinylated derivatives maintained strong chitinase inhibitory activity. Especially, 6 inhibited a Trichoderma chitinase as strongly as 1 .
Databáze:	OpenAIRE
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