Anticancer Activities of bis(pyrazol-1-ylthiocarbonyl)disulfides against HeLa cells

Autor:	Bernard Omondi, Ilia A. Guzei, Frankline K. Keter, Margo Nell, James Darkwa
Rok vydání:	2009
Předmět:	Coupling (electronics) HeLa biology Chemistry Polymer chemistry Disulfide bond chemistry.chemical_element General Chemistry Iodine biology.organism_classification
Zdroj:	Journal of Chemical Research. 2009:322-325
ISSN:	2047-6507 1747-5198
Popis:	Oxidation of the pyrazol-1-yldithiocarbamate compounds {[3,5-R2C3HN2CS2]-(R = H, Me} and indazol-1-lydithiocarbamate by iodine produces the sulfur-sulfur coupling compounds {R'C(S)S-S(S)CR'} (R’ = pyrazolyl, 3,5-dimethylpyrazolyl, indazolyl). All compounds were spectroscopically characterised, and, in some cases, structurally characterised. The X-ray structures reveal that these compounds contain a disulfide bridging the pyrazolylthiocarbonyl units. Two of the three disulfide compounds showed very good anticancer activities against HeLa cells at micromolar concentrations, with the most active compound active being 9.6 times more selective in its activity towards tumour cells than normal cells.
Databáze:	OpenAIRE
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