Autor:	Renate van Well, G. Michelle Poliskie, Mary M. Mader
Rok vydání:	2010
Předmět:	Elimination reaction Deuterium Chemistry Kinetics General Medicine Medicinal chemistry
Zdroj:	ChemInform. 30
ISSN:	1522-2667 0931-7597
Popis:	Mild conditions (1.2 eq. Hg(OAc)2, 1.2 eq. TBAF in 1:1 MeOH/THF; 35 min at 0 °C) have been developed for the protodesilylation of α-dimethylphenylsilyl esters. An enolate-dependent mechanism for the reaction was supported through studies indicating the clean incorporation of deuterium. To further investigate the mechanism, the optimal conditions as well as the kinetics of the reaction were explored.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ec4030faa348f088fbe1f4762342d059 https://doi.org/10.1002/chin.199914039 Zobrazit plný text záznamu Plný text