An asymmetric synthesis of the polyol fragment of the polyene macrolide antibiotic RK-397

Autor:	Teck-Peng Loh, Fan Fu
Rok vydání:	2009
Předmět:	chemistry.chemical_classification Olefin fiber Chemistry Stereochemistry Organic Chemistry Intermolecular force Enantioselective synthesis Polyene Biochemistry Single isomer Catalysis chemistry.chemical_compound Polyol Fragment (logic) Drug Discovery
Zdroj:	Tetrahedron Letters. 50:3530-3533
ISSN:	0040-4039
Popis:	A highly convergent and asymmetric synthesis of the C11–C31 polyol fragment of RK-397 as a single isomer is accomplished via a catalytic enantioselective hetero-Diels–Alder reaction and an intermolecular olefin cross-metathesis as key steps.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ec3bde816692047bd120580ae6bd21f4 https://doi.org/10.1016/j.tetlet.2009.03.019 Zobrazit plný text záznamu Full Text from ScienceDirect