New evidence thatCandida albicanspossesses additional ATP-binding cassette MDR-like genes: implications for antifungal azole resistance
| Autor: | Miki Kasai, Andrea Francesconi, D. Landsman, Thomas J. Walsh, Stephen J. Chanock |
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| Rok vydání: | 1997 |
| Předmět: | |
| Zdroj: | Medical Mycology. 35:133-137 |
| ISSN: | 1460-2709 1369-3786 |
| DOI: | 10.1080/02681219780001021 |
| Popis: | Emergence of resistance of Candida albicans to antifungal triazoles is increasingly recognized as an important cause of refractory mucosal candidiasis in HIV-infected patients. Recently, CDR1, which is thought to be analogous to the human MDR-1 P-glycoprotein, has been cloned in C. albicans. It has been proposed that its expression is partially responsible for fluconazole resistance in C. albicans. This gene is characterized by the presence of an ATP binding cassette (ABC) region and is distinct from the BENr gene which does not encode such a functional domain. As the molecular basis for fluconazole resistance appears to be multifactorial, we considered that there may be other ATP binding cassette-containing MDR genes that may potentially contribute to antifungal azole resistance in C. albicans. We therefore sought to identify potential target sequences that may be derived from candidate genes that share homology with the ATP binding cassette region of the human MDR-1 P-glycoprotein. Degenerate oligonucle... |
| Databáze: | OpenAIRE |
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