Subconjunctival sustained release 5-fluorouracil for glaucoma filtration surgery1
| Autor: | Jie Huang, Li-jun Cui, Nai-xue Sun, Xing-hua Li, Jian-gang Yang |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Pharmacology
Intraocular pressure medicine.medical_specialty genetic structures business.industry medicine.medical_treatment Fistula Ultrasound biomicroscopy Glaucoma General Medicine medicine.disease eye diseases Anesthesia Ophthalmology Toxicity Drug delivery medicine Trabeculectomy Pharmacology (medical) sense organs Bleb (cell biology) business |
| Zdroj: | Acta Pharmacologica Sinica. 29:1021-1028 |
| ISSN: | 1745-7254 1671-4083 |
| DOI: | 10.1111/j.1745-7254.2008.00833.x |
| Popis: | To determine the release characteristics of a 5-fluorouracil-loaded poly (lactic acid) disc (5-FU-PLA-DS) and the effect of sustained drug delivery on the success of glaucoma filtration surgery in rabbit eyes. A method of microspheres accumulated by excessive carriers was used in the preparation of the 5-FU-PLA-DS. The disc was characterized for drug loading, entrapment efficiency, in vitro release, and external morphology. It was then implanted subconjunctivally into rabbit eyes with trabeculectomy. Intraocular pressure, ocular inflammatory reaction, filtration bleb appearance, and persistence were evaluated up to postoperative d 90. A quantitative analysis of 5-fluorouracil (5-FU) was performed in the aqueous humor. Ultrasound biomicroscopy was used to assess the appearance of the filtering fistula. The 5-FU-PLA-DS was produced with the drug-loading of 3.07±0.08 mg (mean±SD). 5-FU was released for 91 d with suppressive concentrations. The decrease in intraocular pressure from baseline was significantly more marked in the 5-FU-PLA-DS-implanted eyes during postoperative d 3-90, and the persistence of bleb and filtration fistula was longer than the control eyes (P |
| Databáze: | OpenAIRE |
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