Degeneration der Netzhautzellen der Ratte bei druckbedingtem Ischämie-Reperfusions-Schaden: Eine elektonenmikroskopische Studie

Autor:	Büchi Er
Rok vydání:	1992
Předmět:	Retina Programmed cell death Karyolysis Pathology medicine.medical_specialty Necrosis Nucleoplasm business.industry Ophthalmology Cytolysis medicine.anatomical_structure Cytoplasm Apoptosis Medicine medicine.symptom business
Zdroj:	Klinische Monatsblätter für Augenheilkunde. 200:494-497
ISSN:	1439-3999 0023-2165
DOI:	10.1055/s-2008-1045804
Popis:	An ischaemia-reperfusion insult to the retina was produced in one eye of 29 rats by transitory elevation of the intraocular pressure. The ultrastructural morphology of the degenerating retinal cells was studied at several time points after the insult. Three morphologically distinct types of cell death could be individualized. Type I exhibited progressive karyolysis and cytolysis and was consistent with necrosis. Type II was characterized by progressive shrinkage and condensation of the nucleus and cytoplasm followed by heterophagic elimination, thus resembling apoptosis. The main features of type III cell death were homogenization of the nucleoplasm and cytoplasm and dilatation of the perinuclear cisternae; thus, they were evocative of "non-lysosomal vesiculate" cell death. Transitional stages were observed as well.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ec27aa9c2146a116af2b9d1db476a1b0 https://doi.org/10.1055/s-2008-1045804 Zobrazit plný text záznamu