| Popis: |
T HE limited availability and the difficult preparation and handling of blood plasma for the treatment of shock represent an urgent indication for continued research on nontoxic, macromolecular substances capable of re-establishing and maintaining over prolonged periods an adequate total blood volume, a normal cell-plasma ratio and a normal bIood viscosity. The coIIoida1 solutions of several nonhematogenous, macromolecuIar substances, such as gum acacia (Bayliss, I 9 I 8)) polyvinyl alcohoI (Stierlen, I 939; Jorns, 1940), gelatin (TayIor and Waters, 1941) and pectin (Hartman, Schelling, Harkins and Brush, 1941), have been recommended for this purpose. However, none of these substitutes is entireIy satisfactory for various reasons, such as difficult sterilization, defective stability, variable purity and chemical composition, antigeny Hueper, Landsberg and Eskridge; Martin and Hueper). If methyl ceIIuIose is presented in the foIlowing report as a new pIasma substitute, it is done for the purpose of cahing attention to a megalomolecular compound which possesses a combination of desirable physicochemica1 properties lacking in the above mentioned agents. |
