Low Placental Growth Factor Across Pregnancy Identifies a Subset of Women With Preterm Preeclampsia
| Autor: | Daniel A. Plymire, Carl A. Hubel, James M. Roberts, Robert W. Powers, David C. Sogin, Don M. Laird, Arun Jeyabalan, Dominick L. Pucci, Saul A. Datwyler, Robin E. Gandley |
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| Rok vydání: | 2012 |
| Předmět: |
Placental growth factor
medicine.medical_specialty Pregnancy business.industry Case-control study Gestational age medicine.disease Preeclampsia medicine.anatomical_structure Endocrinology Blood pressure Placenta Internal medicine embryonic structures Internal Medicine Medicine Gestation business reproductive and urinary physiology |
| Zdroj: | Hypertension. 60:239-246 |
| ISSN: | 1524-4563 0194-911X |
| DOI: | 10.1161/hypertensionaha.112.191213 |
| Popis: | Preeclampsia is a heterogeneous syndrome affecting 3% to 5% of all pregnancies. An imbalance of the antiangiogenic and proangiogenic factors, soluble receptor fms-like tyrosine kinase 1 and placental growth factor (PGF), is thought to contribute to the pathophysiology of preeclampsia. Maternal plasma PGF and soluble receptor fms-like tyrosine kinase 1 were quantified by specific immunoassays in cross-sectional samples from 130 preeclamptic subjects and 342 normotensive controls at delivery and longitudinally in samples from 50 women who developed preeclampsia and 250 normotensive controls. Among women who developed preeclampsia, 46% (n=23) evidenced a pattern of consistently low maternal PGF across pregnancy below the lower 95% CI of controls from 15 weeks' gestation to term. In contrast, the remaining 54% (n=27) of women who developed preeclampsia had maternal PGF concentrations similar to or above (n=7) those of normotensive controls. Subjects with low PGF across pregnancy who developed preeclampsia evidenced significantly higher blood pressure in early pregnancy ( P P P |
| Databáze: | OpenAIRE |
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