A Facile Approach to Catalyst-Free Cyanation and Azidation of Organic Compounds and a One-Pot Preparation of 5-Substituted 1H-Tetrazoles by Using a Dimethyl Sulfoxide–Nitric Acid Combination
| Autor: | Milad Kazemnejadi, Boshra Mahmoudi, Mohammad Ali Nasseri, Seyyedeh Ameneh Alavi |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
chemistry.chemical_classification
010405 organic chemistry Dimethyl sulfoxide Organic Chemistry Strecker amino acid synthesis Potassium cyanide Cyanation 010402 general chemistry 01 natural sciences Aldehyde 0104 chemical sciences chemistry.chemical_compound chemistry Nitric acid Reagent Sodium azide Organic chemistry |
| Zdroj: | Synlett. 30:2290-2294 |
| ISSN: | 1437-2096 0936-5214 |
| Popis: | In this study, cyanations or azidations of imines were performed by using hydroxy(dimethyl)-λ4-sulfanecarbonitrile or azido(dimethyl)-λ4-sulfanol, respectively, prepared in situ by treatment of potassium cyanide or sodium azide with a dimethyl sulfoxide–nitric acid combination. Furthermore, a one-pot preparation of 5-substituted 1H-tetrazole derivatives was carried out by using this reagent combination in the presence of an aldehyde, hydroxylamine hydrochloride, and sodium azide under mild conditions. |
| Databáze: | OpenAIRE |
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