Synthesis and α-Glucosidase Inhibitory Activity of Ursolic Acid, Lupeol, and Betulinic Acid Derivatives

Autor:	Thi-Anh-Tuyet Nguyen, Thuc-Huy Duong, Duc Dung Pham, Jirapast Sichaem, Dinh-Long Huynh, Thi-Thanh-Van Le, Ngoc-Hong Nguyen
Rok vydání:	2021
Předmět:	chemistry.chemical_compound chemistry Ursolic acid Synthetic derivatives Stereochemistry Betulinic acid Ic50 values Plant Science General Chemistry α glucosidase inhibitory General Biochemistry Genetics and Molecular Biology Lupeol
Zdroj:	Chemistry of Natural Compounds. 57:1038-1041
ISSN:	1573-8388 0009-3130
Popis:	Seven synthetic derivatives of ursolic acid, lupeol, and betulinic acid (1a–1b, 2a–2b, and 3a–3c) were synthesized to study their α-glucosidase inhibitory activity. Three of them (2b, 3b, and 3c) are new compounds. Among the synthetic derivatives, betulinic acid analogues 3b and 3c exhibited the best activity against α-glucosidase and is superior to the positive agent, with IC50 values of 35.0 ± 3.37 and 34.0 ± 1.24 μM, respectively.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ec21527f66f6d32964527a7e89e7d4d4 https://doi.org/10.1007/s10600-021-03545-1 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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