Transcription Factor TCF7L2 Genetic Study in the French Population
| Autor: | Raphael Scharfmann, Gema Frühbeck, Bart Staels, Beverley Balkau, Christian Dina, François Pattou, Chantal Samson, Stéphane Cauchi, David Meyre, Hélène Choquet, Philippe Froguel, Guillaume Charpentier, Volodymyr Stetsyuk, Sophie Gallina |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
0303 health sciences
medicine.medical_specialty education.field_of_study endocrine system diseases Endocrinology Diabetes and Metabolism Population Case-control study Adipose tissue 030209 endocrinology & metabolism Type 2 diabetes Biology medicine.disease Transcription Factor 7-Like 2 03 medical and health sciences 0302 clinical medicine Endocrinology Internal medicine Diabetes mellitus Internal Medicine medicine Glucose homeostasis education TCF7L2 030304 developmental biology |
| Zdroj: | Diabetes. 55:2903-2908 |
| ISSN: | 1939-327X 0012-1797 |
| DOI: | 10.2337/db06-0474 |
| Popis: | Recently, the transcription factor 7-like 2 (TCF7L2) gene has been associated with type 2 diabetes in subjects of European origin in the DeCode study. We genotyped the two most associated variants (rs7903146 and rs12255372) in 2,367 French type 2 diabetic subjects and in 2,499 control subjects. Both the T-allele of rs7903146 and the T-allele of rs12255372 significantly increase type 2 diabetes risk with an allelic odds ratio (OR) of 1.69 (95% CI 1.55–1.83) (P = 6.0 × 10−35) and 1.60 (1.47–1.74) (P = 7.6 × 10−28), respectively. In nonobese type 2 diabetic subjects (BMI |
| Databáze: | OpenAIRE |
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