Variant rs2009262 EFEMP1 Is Associated with the Development of Umbilical Hernia but Not with Postoperative Hernia in Russians
| Autor: | I. S. Ivanov, O. Yu. Bushueva, Alexey Polonikov, A. V. Tsukanov, S. V. Ivanov, E. Yu. Klesova |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0106 biological sciences
0303 health sciences medicine.medical_specialty Single-nucleotide polymorphism Biology Logistic regression medicine.disease Lower risk 01 natural sciences Gastroenterology digestive system diseases Umbilical hernia Abdominal wall 03 medical and health sciences surgical procedures operative medicine.anatomical_structure Polymorphism (computer science) Internal medicine Genetics medicine Hernia Genotyping 030304 developmental biology 010606 plant biology & botany |
| Zdroj: | Russian Journal of Genetics. 56:734-738 |
| ISSN: | 1608-3369 1022-7954 |
| Popis: | This study investigated whether rs2009262 EFEMP1 and rs3809060 WT1 single nucleotide polymorphisms are associated with anterior abdominal wall hernia. DNA samples were obtained from 253 patients with anterior abdominal wall hernia (60 males, 193 females, 82 patients with umbilical hernia, 171 patients with postoperative hernia) and 240 age-matched healthy controls (52 males, 188 females). Genotyping was performed by TaqMan-based PCR. Detection of associations between SNPs and hernia risk was performed by logistic regression analysis. We found that the polymorphism rs2009262 EFEMP1 is associated with decreased risk of hernia after adjustment for age and gender (OR = 0.74, 95% CI = 0.56–0.98; P = 0.034). The stratified analysis showed that rs2009262 EFEMP1 is associated with decreased risk of disease only in patients with umbilical hernia (OR = 0.57, 95% CI = 0.37–0.88; P = 0.008). Meanwhile no association between rs2009262 EFEMP1 and postoperative hernia was observed. Our study showed for the first time an association of rs2009262 EFEMP1 with lower risk of umbilical hernia in Russians. |
| Databáze: | OpenAIRE |
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