Amino-acids and peptides. Part IX. Some neighbouring-group amino–amide and hydroxy–amide interactions

Autor:	C. H. Hassall, I. H. Rogers, Jacquita A. Davies
Rok vydání:	1969
Předmět:	chemistry.chemical_classification Hydrolysis chemistry.chemical_compound Chemistry Stereochemistry Group (periodic table) Amide Organic Chemistry polycyclic compounds Peptide chemistry Lactam Amino amide Amino acid
Zdroj:	J. Chem. Soc. C. :1358-1363
ISSN:	0022-4952
Popis:	Base-catalysed hydrolysis studies have provided evidence of neighbouring-group amino–amide interactions in compounds with the formulae H2N·[CH2]x·CO·NHMe (x= 3, 4, or 5), and in 6-aminodecane-10-lactam. Acid-catalysed hydrolysis studies have indicated that transannular hydroxy-amide interactions occur with 4-hydroxyhexane-6-lactam, 5-hydroxyoctane-8-lactam, and 6-hydroxydecane-10-lactam. The mechanisms of these reactions and the significance of such processes in peptide chemistry is discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ec1a16b55a61f3a48d9994ba416fab01 https://doi.org/10.1039/j39690001358 Zobrazit plný text záznamu