Effect of Artificial Stimulants on Cryopreserved Spermatozoa from Cancer Patients

Autor:	Ashok Agarwal, S. Kohn, Rakesh Sharma, Osvaldo F. Padron
Rok vydání:	1997
Předmět:	education.field_of_study medicine.medical_specialty business.industry Urology Population Cancer Semen medicine.disease Sperm Cryopreservation Pentoxifylline Surgery Oligospermia medicine business education Testicular cancer medicine.drug
Zdroj:	Journal of Urology. 157:521-524
ISSN:	1527-3792 0022-5347
DOI:	10.1016/s0022-5347(01)65192-9
Popis:	Purpose: We determined whether cryopreserved sperm samples obtained from cancer patients before treatment respond to artificial motility stimulants and if this response is related to the extent of disease.Materials and Methods: Pre-freeze distribution of disease stage in the different types of cancer and the percentage of the population with or without oligospermia before cryopreservation were examined. Cryopreserved semen samples from 17 cancer patients (10 with testicular cancer, 5 with Hodgkin's disease and 2 with other metastatic disease) were examined for a relationship between post-thaw sperm motion characteristics and patient age or status (survived versus died) and type of disease. Motion characteristics (curvilinear velocity, straight line velocity, average path velocity, linearity and amplitude of lateral head displacement) were analyzed on a computer assisted semen analyzer before (time 0), and 30 and 60 minutes after addition of a 2.5 mM. concentration of pentoxifylline and 2-deoxyaden...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ec1941b1e22e7bcbad7d4bce6ab83ede https://doi.org/10.1016/s0022-5347(01)65192-9 Zobrazit plný text záznamu