Molecular beacon-based NAND logic gate for sensing triplex DNA binders

Autor:	Wei-Lung Tseng, Chia-Yin Kuo, Kai-Cheng Lin, Chih-Chun Nieh
Rok vydání:	2014
Předmět:	General Chemical Engineering Triplex DNA NAND gate Nanotechnology General Chemistry NAND logic Fluorescence Combinatorial chemistry Thymine chemistry.chemical_compound chemistry Molecular beacon Sanguinarine DNA
Zdroj:	RSC Adv.. 4:38389-38392
ISSN:	2046-2069
DOI:	10.1039/c4ra06158f
Popis:	This study developed a thymine-based molecular beacon (MB), which can be used for screening triplex DNA binders and quantifying coralyne and sanguinarine. Triplex DNA binder triggered the formation of triple-stranded DNA between MB and 7-repeat adenosine (A7), switching off the fluorescence of MB. Based on the use of triplex DNA binder and A7 as inputs and the fluorescence change of MB as the output, the NAND gate was constructed to discriminate triplex DNA binders from duplex DNA binders.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ec18498a9a03c08ceec86c5a21ac256d https://doi.org/10.1039/c4ra06158f Zobrazit plný text záznamu