Application of the Kuenz–Leuenberger Equation as a Predictive Model of the Direct Tablet Compression Process

Autor:	S. V. Tishkov, I. V. Bogunova, V. V. Bueva, V. B. Markeev, K. V. Alekseev, E. V. Blynskaya
Rok vydání:	2021
Předmět:	Pharmacology Theoretical computer science Mathematical model Chemistry Process (engineering) Compression (functional analysis) Drug Discovery Pharmacology toxicology
Zdroj:	Pharmaceutical Chemistry Journal. 55:604-615
ISSN:	1573-9031 0091-150X
DOI:	10.1007/s11094-021-02465-2
Popis:	Mathematical models, the most widely applied of which are the Heckel and Kawakita models, are used in modern research on the compression process to estimate tablet mechanical properties. However, these models have several limitations associated with the inability to consider all processes occurring in parallel during interparticle interaction. In 1999, a group of scientists developed a new approach based on the so-called Kuenz–Leuenberger equation. The present article analyzed modern research on the applicability of this equation for comparing the most common models used for describing the tablet compression process.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ec079b623568077a4003fc59a0a7a9fa https://doi.org/10.1007/s11094-021-02465-2 Zobrazit plný text záznamu Plný text ve formátu PDF