| Popis: |
From the point of view of protein structure and catalytic mechanism, phospholipases A2 (PLA2’s) are among the best characterized enzymes. Most of what is known about the structure and enzymology of PLA2 is based on studies using the enzymes purified from snake venom and mammalian pancreas (1, 2). Although it has been known for some time that PLA2 activity can be found in virtually every tissue and cell type (3, 4), these cellular PLA2’s are present in only trace amounts, and, until recently, efforts to purify and characterize them have been impeded. Thus, despite an extensive knowledge of the structure and enzymology of PLA2, based on the paradigm of the pancreatic and snake venom enzymes, much remains to be learned regarding different cellular forms of PLA2, their physiological roles, and how PLA2 activity is regulated in cells. |
