Augmented Pulmonary Vascular and Venous Constrictions to NG-Nitro-L-Arginine Methyl Ester in Rats with Monocrotaline-Induced Pulmonary Hypertension
| Autor: | Susan W. S. Leung, Xing Cheng, Catherine C.Y. Pang, Su Lin Lim |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Pharmacology
medicine.medical_specialty Cardiac output ATP synthase biology Pyrrolizidine alkaloid General Medicine medicine.disease Pulmonary hypertension Nitric oxide chemistry.chemical_compound Blood pressure medicine.anatomical_structure chemistry Internal medicine Nitro biology.protein Cardiology medicine Vascular resistance |
| Zdroj: | Pharmacology. 69:164-170 |
| ISSN: | 1423-0313 0031-7012 |
| DOI: | 10.1159/000072670 |
| Popis: | The hemodynamic effects of NG-nitro-L-arginine methyl ester (L-NAME, inhibitor of nitric oxide (NO) synthase) were examined in thiobutabarbital-anesthetized controlrats and rats with monocrotaline-induced pulmonary hypertension. L-NAME (1–16 mg/kg i.v.) increased mean arterial pressure, systemic vascular resistance, venous resistance and pulmonary vascular resistance, and decreased cardiac output in both the control and pulmonary hypertensive rats. Relative to the controls, L-NAME (16 mg/kg) caused a smaller increase (≈50% of control) in mean arterial pressure in the pulmonary hypertensive rats, but greater increases in venous (≈200%) as well as pulmonary vascular (≈400%) resistances and a greater decrease in cardiac output (≈140%). The results show that NO is an important dilator within the arterial, venous and pulmonary circulation; its pulmonary and venous dilator roles are augmented in pulmonary hypertension. |
| Databáze: | OpenAIRE |
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