Pseudopolymorph Control of l -Phenylalanine Achieved by Laser Trapping
| Autor: | Hiroshi Masuhara, Teruki Sugiyama, Ken-ichi Yuyama, Pei-Yun Hsieh, Chi-Shiun Wu |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Supersaturation
Materials science Analytical chemistry 02 engineering and technology General Chemistry 010402 general chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics 01 natural sciences 0104 chemical sciences law.invention Crystal symbols.namesake Whisker law symbols Anhydrous General Materials Science Laser power scaling Crystallization 0210 nano-technology Saturation (chemistry) Raman spectroscopy |
| Zdroj: | Crystal Growth & Design. 18:5417-5425 |
| ISSN: | 1528-7505 1528-7483 |
| Popis: | We demonstrate pseudopolymorph control of l-phenylalanine (l-Phe) with laser trapping method by tuning laser power, polarization, and initial solution concentration. When a continuous-wave near-infrared laser beam of 1064 nm was focused at an air/solution interface of l-Phe D2O solutions with different saturation, l-Phe crystallization was always observed within 30 min-irradiation, even from unsaturated solution. Either whisker- or plate-like crystals were generated depending on given conditions, and identified by Raman spectroscopy to be two l-Phe pseudopolymorphs of monohydrate and anhydrous forms, respectively. The absolute control of l-Phe pseudopolymorphism was achieved by changing the initial solution concentration. In unsaturated solution, laser trapping always produced only one anhydrous crystal at the focus, which can never be produced on spontaneous nucleation at ordinary temperatures and pressures, while in supersaturated solution, a number of monohydrate crystals were densely distributed in an... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|