Validation of a Mimic Heart Failure Model
| Autor: | Ping Yang, Nathan A. Grenz, Pierre Bordachar, Douglas S. Hine, Nicole Kirchhof |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Ejection fraction Ischemic cardiomyopathy Left bundle branch block business.industry medicine.disease Coronary arteries QRS complex medicine.anatomical_structure Ventricle Heart failure Internal medicine cardiovascular system medicine Cardiology cardiovascular diseases Circumflex Cardiology and Cardiovascular Medicine business |
| Zdroj: | Journal of Arrhythmia. 27:PE2_017 |
| ISSN: | 1883-2148 1880-4276 |
| DOI: | 10.4020/jhrs.27.pe2_017 |
| Popis: | Introduction: Animal models which mimic the clinical characteristics of heart failure (HF) with dyssynchrony play a critical role in development of new therapies. Existing HF animal models created by left bundle branch block (LBBB), rapid pacing, or microembolization alone or in combinations only mimic partial HF characteristics and are time-costuming and expensive. The microembolization model creates a stable reduction in left ventricular ejection fraction (LVEF) with minimal change in QRS. Methods: Ten dogs were implanted with two epicardial leads on the left ventricle (LV) and LBBB ablation increased QRS width by 2×. After 4 weeks, HF was induced by microembolization procedures every 1–3 weeks by injecting microspheres into one or both of the coronary arteries (LAD and Left Circumflex) until LVEF decreased to |
| Databáze: | OpenAIRE |
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