Autor:	Maria Luisa Campo, Concepción Muro, Kathleen W. Kinnally
Rok vydání:	2000
Předmět:	Transmembrane channels Physiology Putative protein food and beverages Cell Biology Mitochondrion Biology Cell biology Transport protein Membrane Biochemistry Organelle Bioorganic chemistry Ion channel
Zdroj:	Journal of Bioenergetics and Biomembranes. 32:47-54
ISSN:	0145-479X
DOI:	10.1023/a:1005560328334
Popis:	All but a small fraction of the hundreds of proteins in a mitochondrion are synthesized in thecytoplasm and imported into the organelle. Water-filled channels are integral to the process oftranslocating proteins since channels can provide an aqueous pathway through the hydrophobicenvironment of the membrane. The MCC (multiple conductance channel) and PSC(peptide-sensitive channel) are two high-conductance channels previously identified inelectrophysiological studies of mitochondrial membranes. MCC and PSC are the putative pores of the importcomplexes of the inner and outer membranes, respectively. The genetic, biochemical, andbiophysical evidence regarding these assignments are summarized herein. These findingssupport the identification of MCC and PSC as the protein import channels of mitochondria.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ebe7e31ffda6421d8b2881f28d01fd4c https://doi.org/10.1023/a:1005560328334 Zobrazit plný text záznamu Full text from SpringerLink